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Corporate

Leading with Purpose: Biomol’s Commitment to Its Team and Leadership

Teams are the driving force behind every organization, while leaders serve as the compass that inspires and guides the creation of corporate cultures focused on positive impact. At Biomol, we are fully aware of this reality. That is why we have taken a step forward to strengthen our leadership from within, reinforcing our internal leadership …

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Biomedicine

Clinical Implementation of the Molecular Algorithm for Ph-Negative MPN in Collaboration with the Hospital of Jerez

From the Support and Applications Department at BIOMOL, we share a recent case of implementing a complete diagnostic workflow for Philadelphia-negative Myeloproliferative Neoplasms (Ph-negative MPNs), developed in collaboration with the Hematology Department of the University Hospital of Jerez de la Frontera. The objective was to structure a sequential algorithm that enables accurate identification of mutations …

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Fragmentation

DNA Fragmentation in NGS: What Do I Need to Understand and How Does It Affect My Sequencing Project?

Nucleic acid purification methodologies are the foundational pillar of molecular analysis techniques in biomedicine. The starting samples are highly diverse, ranging from cell isolates to formalin-fixed or paraffin-embedded tissues, and include techniques from endpoint PCR to high-throughput sequencing. Therefore, the impact of different genetic material fragmentation techniques can increase accuracy, enable the development of error-correction …

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Genetics

Covaris AFA Technology: Innovation in FFPE Sample Processing for DNA, RNA and Proteins

Covaris’ Adaptive Focused Acoustic Technology (AFA) represents a revolutionary breakthrough in sample preparation for genomic and proteomic analysis. This technology uses high-frequency, high-precision ultrasound to perform mechanical processes such as DNA and RNA fragmentation, protein extraction, and sample homogenisation. Designed to work in clinical and research environments, AFA stands out for its ability to process …

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Biomedicine

The discovery of the transcriptome at tissular level: A new approach in biomedicine

Spatial resolved transcriptomics (SRT) is a technology that maps gene expression within a tissue from two perspectives: image-based and NGS-based. The applications in biomedicine are evident, especially in the characterization of tumor heterogeneity and identification of structures while shedding light to sequencing techniques such as single-cell-seq from a tissular context perspective. How spatial transcriptomics improves …

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Biopsy

Liquid Biopsy. Molecular análisis of CTCs and circulating tumor DNA. The triumph of multi-omics from a blood sample

The increase in prevalence and incidence rates of cancer worldwide requires effective diagnostic and treatment selection strategies and one of the challenges to overcome is the dynamic panorama of the disease, known as tumor heterogeneity, where intra and intro heterogeneity mark a difference and require continuous and precise monitoring methods. This heterogeneity is the fundamental …

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