Biomedicine 28 de July de 2026

Automated NGS in Oncology with Ion Torrent Genexus

Automated NGS in oncology to accelerate genomic analysis, reduce hands-on time and deliver faster results with Ion Torrent Genexus.

Precision medicine requires fast, reliable and actionable results. In this context, automated NGS in oncology has become a key tool for accelerating genomic analysis and supporting decision-making in the laboratory.

The Ion Torrent Genexus system is designed to simplify access to Next-Generation Sequencing (NGS). Its integrated workflow helps reduce operational complexity, minimize manual intervention and bring advanced genomic analysis closer to laboratories with different levels of NGS experience.

What is Ion Torrent Genexus?

Automated NGS workflow from sample processing to data analysis and results.

Ion Torrent Genexus is an integrated NGS platform that combines automation, speed and flexibility. The system includes the Genexus Purification System and the Genexus Integrated Sequencer.

Together, they automate several stages of the workflow, including:

Nucleic acid extraction.
Quantification.
Library preparation.
Sequencing.
Data analysis.
Result generation.

All of this is achieved with only two user touchpoints and less than 20 minutes of hands-on time. As a result, this level of automation helps reduce sample handling, minimize potential operational errors and improve laboratory efficiency.

In addition, the system enables next-day NGS results, which is especially valuable in areas where turnaround time is critical.

Automated NGS to reduce turnaround times

Turnaround time comparison between outsourced and automated in-house NGS.

One of the main challenges of NGS in oncology is the time required to obtain results. When samples are sent to external laboratories, turnaround times can range from 10 to 14 days.

However, automated NGS panels based on amplicon technology allow laboratories to perform genomic profiling in-house. This can reduce turnaround time to approximately 1–3 days.

Moreover, keeping the workflow in the laboratory improves control over the sample, pre-analytical parameters and tissue preservation. Therefore, this approach supports a more agile implementation of NGS while maintaining greater control over the entire process.

Key advantages of the Ion Torrent Genexus system

Ion Torrent Genexus provides an integrated solution for laboratories looking to implement or expand their NGS capabilities in oncology.

Fast results

The system enables next-day NGS results, reducing the time associated with more manual or outsourced workflows.

Automated workflow

The platform integrates the process from sample or nucleic acid to result. In addition, it supports run planning, instrument monitoring, data analysis and result review through Genexus Software.

Low input and robust performance

Amplicon-based technology enables analysis from low amounts of starting material. This makes it easier to work with samples that may not be sufficient for other genomic profiling approaches.

Scalability and flexibility

Oncomine assays allow laboratories to adapt NGS analysis to different needs. The platform supports applications for solid tumors, liquid biopsy, BRCA and oncohematology, as well as custom Ion AmpliSeq™ panels for research.

Applications of Ion Torrent Genexus in oncology

Broad genomic profiling of up to 517 DNA and RNA genes in tumor samples.

In solid tumors, Ion Torrent Genexus enables laboratories to analyze anything from key biomarkers to broad genomic profiles covering 517 DNA and RNA genes.

In addition, it can incorporate complex biomarkers such as:

HRD.
TMB.
MSI.

This approach allows multiple genomic alterations to be analyzed within a single workflow, including SNVs, indels, fusions, CNVs and genomic signatures.

NGS detection of SNVs, indels, fusions, CNVs and genomic signatures.

The platform also extends its applications to BRCA, hematological samples and lymphoid disorders. In this way, it offers an automated and flexible workflow for both translational research and laboratories seeking to implement NGS across different analytical needs.

Genexus Software: integrated analysis in a single environment

Genexus Software supports the entire workflow within a single platform. It integrates sample management, run planning, result review and report generation.

Its interface allows laboratories to view quality metrics, key variants and relevant findings in an organized way. This helps make NGS data interpretation faster and more efficient.

Thanks to this integrated environment, laboratories can transform sequencing data into clear and actionable results.

Towards faster, more accessible and automated NGS

With Ion Torrent Genexus, laboratories can move towards a faster, more flexible and more efficient model of automated NGS in oncology.

From targeted panels to comprehensive genomic profiling of more than 500 genes, the platform supports a wide range of applications in solid tumors, liquid biopsy, BRCA and oncohematology.

Less hands-on time. More automation. Faster results. More applications on a single platform.

At Biomol, we support laboratories in the implementation of advanced solutions for molecular biology, diagnostics and biomedical research, providing specialized guidance and technical support throughout the process.